Comparison of the damage-promoting effects of leukotrienes derived from eicosapentaenoic acid and arachidonic acid on the rat stomach

@article{Wallace1990ComparisonOT,
  title={Comparison of the damage-promoting effects of leukotrienes derived from eicosapentaenoic acid and arachidonic acid on the rat stomach},
  author={John L Wallace and Gordon Webb McKnight},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={171},
  pages={1827 - 1832}
}
The ability of leukotrienes derived from eicosapentaenoic acid were compared with counterpart leukotrienes derived from arachidonic acid in terms of their ability to affect susceptibility of the stomach to injury induced by a topical irritant and their ability to alter gastric blood flow. Intra-arterial infusion of leukotriene C4 (LTC4) and LTD4 (0.1-3 micrograms/kg/min for 5 min) produced dose-dependent increases in gastric mucosal damage induced by topically applied 20% ethanol, as assessed… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 12 references

Lipid mediators ofinflammation in gastric ulcer

J. L. Wallace
Am . J Physiol . • 1990

Prevention of cysteamine - induced duodenal ulcers by dietary fish oil

F. Guarner, J. Vilaseca, +3 authors J.-R. Malagelada
Gastroenterology . • 1989

Fish oil protection against absolute ethanol induced gastric injury

F. W. Leung
Gastroenterology • 1988

Leukotrien e B 3 , leukotriene B 4 and leukotriene B 5 : binding to leukotriene B 4 receptors on rat and human leukocyte membranes

S. Charleston, J. F. Evans, +5 authors A. W. Ford-Hutchinson
Prostaglandins . • 1986

Gastric mucosal blood flow measured by laser - Doppler velicometry

D. W. Goldman, W. C. Pickett
Am . J Physiol . • 1985

Biosynthesis and biological activity of leukotriene B 5

S Hammarstrom
Prostaglandins • 1984

Reduction ofethanolinduced gastric mucosal damage by cytoprotective agents : a correlated morphological and physiological study

L WallaceJ., G . P. Morris, E .J . Krausse, S . E . Greaves
Can . J. Physiol. Pharmacol • 1982

Similar Papers

Loading similar papers…