Comparison of the cytotoxic response against ovarian cancer by immune effector cells isolated and expanded from normal donors and ovarian cancer patients.

@article{Ingersoll2012ComparisonOT,
  title={Comparison of the cytotoxic response against ovarian cancer by immune effector cells isolated and expanded from normal donors and ovarian cancer patients.},
  author={Susan Blaydes Ingersoll and Gregory P. Stoltzfus and Mohammed H. Merchant and Sarvat M. Ahmad and Collin R. Edwards and Ahad Shahid Ahmed and Jeremiah L Oyer and Neil J. Finkler and Robert W. Holloway and John Richard Edwards},
  journal={Cytotherapy},
  year={2012},
  volume={14 6},
  pages={
          716-23
        }
}
BACKGROUND/AIMS The aim of this study was to compare the cytotoxic response against ovarian cancer (OC) cells elicited by different immune effector cells in combination with the cytokines interleukin (IL)-2 and interferon (IFN) α-2b. METHODS OC cells were co-cultured with peripheral blood mononuclear cells (PBMC) from normal donors or OC patients and IL-2 or IFN α-2b alone or in combination, in order to determine the cytotoxicity. T cells were isolated from healthy donors to determine T cell… CONTINUE READING
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