Comparison of the cytotoxic effect of lapachol, α-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells

@article{Salustiano2009ComparisonOT,
  title={Comparison of the cytotoxic effect of lapachol, α-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells},
  author={Eduardo Jesus Salustiano and Chaquip Daher Netto and Renata F. Fernandes and Alcides Jos{\'e} M. da Silva and Thiago de S{\'a} Bacelar and Carolina Pereira Castro and Camilla Djenne Buarque and Raquel Ciuvalschi Maia and Vivian M. Rumjanek and Paulo Roberto Costa},
  journal={Investigational New Drugs},
  year={2009},
  volume={28},
  pages={139-144}
}
The pentacyclic 1,4-naphthoquinones 1a–d were cytotoxic (IC50 ∼ 2–7 μM) to human leukemic cell lines K562 (oxidative stress-resistant), Lucena-1 (MDR phenotype) and Daudi. Fresh leukemic cells obtained from patients, some with the MDR phenotype, were also sensitive to these compounds. The pentacyclic 1,4-naphthoquinones 1a and 1c induced apoptotic cell death in cells from leukemic patients as determined by flow cytometry. Conversely, the cell lines were highly insensitive to lapachol (2) and… CONTINUE READING

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