Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols

  title={Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols},
  author={St{\'e}phanie Lemaire-Ewing and C{\'e}line Prunet and Thomas Montange and Anne Vejux and Arnaud Berthier and Ginette Bess{\`e}de and Laurent Corcos and Philippe Gambert and D. Neel and G{\'e}rard Lizard},
  journal={Cell Biology and Toxicology},
Oxidized low-density lipoproteins play important roles in the development of atherosclerosis and contain several lipid-derived, bioactive molecules which are believed to contribute to atherogenesis. Of these, some cholesterol oxidation products, refered to as oxysterols, are suspected to favor the formation of atherosclerotic plaques involving cytotoxic, pro-oxidant and pro-inflammatory processes. Ten commonly occurring oxysterols (7α-, 7β-hydroxycholesterol, 7-ketocholesterol, 19… CONTINUE READING


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