Comparison of the cromakalim antagonism and bradycardic actions of a series of novel alinidine analogues in the rat

Abstract

Alinidine, and eight derivatives, were synthesized and tested for their ability to antagonise the actions of the K+ channel opener cromakalim in rat thoracic aorta, and for their ability to induce bradycardia in rat isolated spontaneously beating right atria. Ring segments of rat thoracic aorta were suspended in organ baths to record isometric tension… (More)
DOI: 10.1007/BF00241091

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