Comparison of the critical concentration and critical volume hypotheses to model non-specific toxicity of individual compounds.

@article{Warne1991ComparisonOT,
  title={Comparison of the critical concentration and critical volume hypotheses to model non-specific toxicity of individual compounds.},
  author={Michael Stj Warne and David W. Connell and Darryl William Hawker},
  journal={Toxicology},
  year={1991},
  volume={66 2},
  pages={
          187-95
        }
}
The critical concentration and critical volume hypotheses for non-specific toxicity require the molar concentration (CC) and volume fraction (VF) of toxicant in target tissue to be constant. Thus these factors should be independent of the octanol-water partition coefficient (Kow) for individual compounds. CC and VF values were calculated based on acute sub-lethal, acute and chronic lethal toxicity data, Kow and pure component molar volume (MV) data. When these values were plotted against log… CONTINUE READING
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