Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: A randomised controlled study

@article{Karakurt2008ComparisonOT,
  title={Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: A randomised controlled study},
  author={Feridun Karakurt and Ibrahim Sahin and Serdar G{\"u}ler and Berrin Demirbaş and Cavit Culha and R{\"u}şt{\"u} Serter and Yalçın Aral and Nuket Bavbek},
  journal={Advances in Therapy},
  year={2008},
  volume={25},
  pages={321-328}
}
Introduction: Hirsutism is commonly a consequence of ovarian androgen over-production. Polycystic ovary syndrome (PCOS) or peripheral hypersensitivity to normal androgen circulating levels (idiopathic hirsutism) can be the underlying cause. Several drugs with anti-androgenic properties, such as cyproterone acetate (CPA), spironolactone and flutamide have been used to treat hirsutism, but the efficacy of these drugs has yet to be fully elucidated. The objective of this study was to compare the… 
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28 Citations

The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms – a review
TLDR
It is shown that therapeutic response in women with hirsutism requires a long-term approach and that hyperandrogenic skin symptoms in patients with PCOS are efficiently treated, allowing both health care professionals and women to balance the risks and benefits of treatment based on evidence.
Comparison of spironolactone and spironolactone plus metformin in the treatment of polycystic ovary syndrome
  • H. Diri, S. Karaburgu, F. Keleştimur
  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2016
TLDR
FGSs were significantly decreased in both groups; however, combination therapy was not more effective than spironolactone alone in terms of BMI, FGS, hormone levels, or insulin resistance.
A Comparative Study of Diane‐35 plus Spironolactone and Diane ‐35 Plus Finasteride in Cases of Hirsutism and Acne
TLDR
Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne and it is recommended that the treatment period be over 12 months.
In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone.
Odabir hormonske kontracepcije ovisno o fenotipu sindroma policističnih jajnika
This paper represents a critical review of the data considering the effects combined hormonal contraceptives (CHC) might have on patients with polycystic ovary syndrome (PCOS), with an aim to…
Total , Free Testosterone and Insulin Hormone Levels in Patients with Hirsutism
TLDR
The results showed that the total testosterone hormone and free testosterone are increased significantly in the female patients with hirsutism compared to control group and basal insulin found to be significantly increased when compared with control group.
4 Polycystic Ovary Syndrome
TLDR
These criteria recognize that PCOS is a functional disorder in which ovarian hyperandrogenism can occur in the presence or absence of ovarian morphologic changes, however, according to Rotterdam criteria or AES criteria, polycystic ovaries need not to be fulfilled.
Comparison of desogestrel/ethinyl estradiol plus spironolactone versus cyproterone acetate/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial
TLDR
To compare the effects of ethinyl estradiol plus spironolactone 25 mg/day versus EE 35 mcg/cyproterone acetate 2‬mg (group B) on hyperandrogenism and metabolism in PCOS, a comparison study is conducted on rats.
Interventions for hirsutism (excluding laser and photoepilation therapy alone).
TLDR
There was low quality evidence for the effect of two oral contraceptive pills (OCPs) and change in androgen levels were addressed in most comparisons, change in body mass index (BMI) and improvement of other clinical signs of hyperandrogenism in one-third of studies.
Hormonal contraceptive choice for women with PCOS: a systematic review of randomized trials and observational studies
TLDR
A critical review of the data concerning the effects of combined hormonal contraceptives (CHC) for polycystic ovary syndrome (PCOS) to determine the best treatment option for each PCOS phenotype.
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