Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: A randomised controlled study

  title={Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: A randomised controlled study},
  author={Feridun Karakurt and Ibrahim Sahin and Serdar G{\"u}ler and Berrin Demirbaş and Cavit Culha and R{\"u}şt{\"u} Serter and Yalçın Aral and Nuket Bavbek},
  journal={Advances in Therapy},
Introduction: Hirsutism is commonly a consequence of ovarian androgen over-production. Polycystic ovary syndrome (PCOS) or peripheral hypersensitivity to normal androgen circulating levels (idiopathic hirsutism) can be the underlying cause. Several drugs with anti-androgenic properties, such as cyproterone acetate (CPA), spironolactone and flutamide have been used to treat hirsutism, but the efficacy of these drugs has yet to be fully elucidated. The objective of this study was to compare the… 
The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms – a review
It is shown that therapeutic response in women with hirsutism requires a long-term approach and that hyperandrogenic skin symptoms in patients with PCOS are efficiently treated, allowing both health care professionals and women to balance the risks and benefits of treatment based on evidence.
Comparison of spironolactone and spironolactone plus metformin in the treatment of polycystic ovary syndrome
  • H. Diri, S. Karaburgu, F. Keleştimur
  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2016
FGSs were significantly decreased in both groups; however, combination therapy was not more effective than spironolactone alone in terms of BMI, FGS, hormone levels, or insulin resistance.
A Comparative Study of Diane‐35 plus Spironolactone and Diane ‐35 Plus Finasteride in Cases of Hirsutism and Acne
Diane 35 plus spironolactone and Diane 35 plus finasteride are equally effective and safe in the treatment of hirsutism and acne and it is recommended that the treatment period be over 12 months.
Odabir hormonske kontracepcije ovisno o fenotipu sindroma policističnih jajnika
This paper represents a critical review of the data considering the effects combined hormonal contraceptives (CHC) might have on patients with polycystic ovary syndrome (PCOS), with an aim to
Total , Free Testosterone and Insulin Hormone Levels in Patients with Hirsutism
The results showed that the total testosterone hormone and free testosterone are increased significantly in the female patients with hirsutism compared to control group and basal insulin found to be significantly increased when compared with control group.
4 Polycystic Ovary Syndrome
These criteria recognize that PCOS is a functional disorder in which ovarian hyperandrogenism can occur in the presence or absence of ovarian morphologic changes, however, according to Rotterdam criteria or AES criteria, polycystic ovaries need not to be fulfilled.
Comparison of desogestrel/ethinyl estradiol plus spironolactone versus cyproterone acetate/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial
To compare the effects of ethinyl estradiol plus spironolactone 25 mg/day versus EE 35 mcg/cyproterone acetate 2‬mg (group B) on hyperandrogenism and metabolism in PCOS, a comparison study is conducted on rats.
Interventions for hirsutism (excluding laser and photoepilation therapy alone).
There was low quality evidence for the effect of two oral contraceptive pills (OCPs) and change in androgen levels were addressed in most comparisons, change in body mass index (BMI) and improvement of other clinical signs of hyperandrogenism in one-third of studies.
Hormonal contraceptive choice for women with PCOS: a systematic review of randomized trials and observational studies
A critical review of the data concerning the effects of combined hormonal contraceptives (CHC) for polycystic ovary syndrome (PCOS) to determine the best treatment option for each PCOS phenotype.


Finasteride versus cyproterone acetate–estrogen regimens in the treatment of hirsutism
  • A. Beigi, A. Sobhi, F. Zarrinkoub
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2004
Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial.
After a 6-month course of therapy, the clinical efficacies of these drugs, at least at the doses used, are similar and are all effective in the treatment of hirsutism.
Contraceptive and therapeutic effectiveness of two low-dose ethinylestradiol and cyproterone acetate regimens in the treatment of hirsute patients.
  • S. Venturoli, B. Ravaioli, C. Flamigni
  • Medicine, Biology
    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
  • 1998
Both treatments greatly improve hirsutism, reduce clinical problems and side-effects, guarantee both anovulation and contraceptive effectiveness and afford an optimal control of the menstrual cycle.
Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome.
  • E. Pucci, A. Genazzani, A. Genazzani
  • Medicine, Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 1995
It is demonstrated that hirsutism in PCOS can rapidly and markedly respond to treatment with flutamide alone without important side-effects even if administered for a long period.