Comparison of the calcium entry blockers nimodipine and flunarizine on human cerebral and temporal arteries: role in cerebrovascular disorders

@article{Jansen1991ComparisonOT,
  title={Comparison of the calcium entry blockers nimodipine and flunarizine on human cerebral and temporal arteries: role in cerebrovascular disorders},
  author={Ingeborg Jansen and Peer Carsten Tfelt-Hansen and Lars Edvinsson},
  journal={European Journal of Clinical Pharmacology},
  year={1991},
  volume={40},
  pages={7-15}
}
The effect of the calcium entry blockers flunarizine and nimodipine on isolated human cerebral and temporal arteries has been studied. Flunarizine induced only weak relaxation of precontracted temporal arteries in contrast to the response seen in cerebral arteries. Nimodipine invariably induced strong relaxation of both types of vessel. The effect of the calcium entry blockers on potassium (K+)-, noradrenaline (NA)- and 5-hydroxytryptamine (5-HT)-induced contraction was also examined. In… CONTINUE READING