Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer.

@article{Shah2002ComparisonOT,
  title={Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer.},
  author={Rajal B Shah and Ming Zhou and Mich{\`e}le Leblanc and Matthew Snyder and Mark A. Rubin},
  journal={The American journal of surgical pathology},
  year={2002},
  volume={26 9},
  pages={
          1161-8
        }
}
The basal cell-specific cytokeratin antibody (34betaE12) is widely used to aid in the diagnosis of cancer in challenging prostate needle biopsies (NBX) and transurethral resections of the prostate (TURP). Because prostate carcinoma (PCa) lacks basal cells, the absence of basal cell as determined by 34betaE12 can aid in the confirmation of a histologically suspicious lesion. However, false-negative staining occurs because of patchy cytoplasmic staining, making a definitive diagnosis difficult. A… CONTINUE READING

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