Comparison of the autolyzed and unautolyzed forms of mu- and m-calpain from bovine skeletal muscle.

@article{Edmunds1991ComparisonOT,
  title={Comparison of the autolyzed and unautolyzed forms of mu- and m-calpain from bovine skeletal muscle.},
  author={Tim Edmunds and P A Nagainis and Shridhar K Sathe and Valery F. Thompson and Darrel E. Goll},
  journal={Biochimica et biophysica acta},
  year={1991},
  volume={1077 2},
  pages={197-208}
}
Bovine skeletal muscle mu- and m-calpain autolyze when incubated with Ca2+. During the first 30 to 300 s, autolysis: (1) has little effect on the specific proteolytic activity of either mu- or m-calpain when assayed at 5 mM Ca2+; and (2) produces two new proteolytically active forms of calpain in addition to the original mu- and m-calpain. The four… CONTINUE READING