Comparison of the antiinflammatory effects of Drosera rotundifolia and Drosera madagascariensis in the HET‐CAM assay

  title={Comparison of the antiinflammatory effects of Drosera rotundifolia and Drosera madagascariensis in the HET‐CAM assay},
  author={Dietrich H. Paper and Elisabeth Karall and Michaela Kremser and Liselotte Krenn},
  journal={Phytotherapy Research},
The antiinflammatory effects of ethanol and aqueous extracts from Drosera rotundifolia and from Drosera madagascariensis were compared in vivo in the HET‐CAM assay. Both extracts from D. rotundifolia and the ethanol extract from D. madagascariensis showed remarkable efficacy at doses of 500 µg/pellet. The inhibition of the inflammation by the extracts was stronger than that by 50 µg hydrocortisone/pellet. In contrast, there was only a very weak effect observed at a dose of 500 µg/pellet of the… 

Effects of Extracts and Flavonoids from Drosera rotundifolia L. on Ciliary Beat Frequency and Murine Airway Smooth Muscle

It is shown, for the first time, that a Drosera extract and its flavonoid compounds increase the CBF of murine airways while antispasmodic effects were transferred to ASM.

Low-dose Drosera rotundifolia induces gene expression changes in 16HBE human bronchial epithelial cells

D. rotundifolia 3× did not impair cell viability and was shown to be a stimulant of cell functions by regulating the expression of dozens of genes after 3 h, and the effects were amplified after 6 h of treatment.

Phytochemistry of the Carnivorous Sundew Genus Drosera (Droseraceae) – Future Perspectives and Ethnopharmacological Relevance

An updated, comprehensive listing of the phytochemical constituents of the Drosera species is presented, and important factors which may influence the production of phytopharmaceuticals in plants are critically examined, including environmental influences and in vitro culture.

Evaluation of the Antioxidant and Antimicrobial Properties of in vitro Cultured Drosera intermedia Extracts

Antimicrobial activity was tested against seven bacterial and eight yeast strains using the agar diffusion assay, followed by the determination of minimum inhibitory concentrations (MIC).

Antimicrobial Activity of Drosera rotundifolia L.

The best antimicrobial activity of ethanolic extract Drosera rotundifolia L.11 against Salmonella enteritidis was found at Dro Seracae spp.

Variations of Naphthoquinone Levels in Micropropaaated Drosera Species In Vitro, under Qreenhouse and Outdoor Growth Conditions

The results underline that in the cultivation of the medicinally useful carnivorous genus Drosera species-specific differences in the biosynthesis of secondary metabolites under different environmental conditions have to be taken into consideration.


The augmentation of firing rates in a high percentage of PGi neurons after the extract injection provides evidence about the role of paragigantocellularis nucleus in reduction of pain in the acute phase of the formalin test.

Identification and quantification of flavonoids and ellagic acid derivatives in therapeutically important Drosera species by LC–DAD, LC–NMR, NMR, and LC–MS

The LC–DAD method for quantification enables, for the first time, separation and precise analysis of these analytes in Droserae herba, and is excellently suited to quality control of the drug or herbal medicinal products containing this drug.



Anti-inflammatory and spasmolytic activity of extracts from Droserae herba.

  • M. MelzigH. PertzL. Krenn
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2001
An ethanolic extract of Drosera madagascariensis inhibited human neutrophil elastase with an IC50 of 9.4 microg/ml, and induced a spasmolytic effect via affecting cholinergic M3 receptors and histamine H1 receptors of guinea-pig trachea.

Investigation of the antiinflammatory activity of liquid extracts of Plantago lanceolata L.

The ability of four liquid extracts of Plantago lanceolata L. to inhibit membrane irritation on the chick chorioallantoic membrane is demonstrated.

A new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryo.

An inflammatory response induced on the chorio-allantoic membrane of the eight-day-old chick embryo, and its reduction by known anti-inflamma-tory agents, both steroidal and non-steroidal are described.

Determination of Naphthoquinones in Droserae herba by Reversed-Phase High Performance Liquid Chromatography

Abstract The naphthoquinones plumbagin and 7-methyljuglone are considered to be responsible for the spasmolytic and antimicrobial properties of sundew herb (Hb. Droserae), used mainly in pediatrics

[An active substance isolated from Drosera rotundifolia].

  • R. Krahl
  • Chemistry, Medicine
  • 1956