Comparison of the antidepressants reboxetine, fluvoxamine and amitriptyline upon spontaneous pupillary fluctuations in healthy human volunteers

@article{Phillips2000ComparisonOT,
  title={Comparison of the antidepressants reboxetine, fluvoxamine and amitriptyline upon spontaneous pupillary fluctuations in healthy human volunteers},
  author={Mick A Phillips and Panos Bitsios and Elem{\'e}r Szabadi and Christopher M. Bradshaw},
  journal={Psychopharmacology},
  year={2000},
  volume={149},
  pages={72-76}
}
Rationale: Spontaneous fluctuations in the size of the pupil in darkness are a recognised index of ”sleepiness”. Objective: To evaluate the effects of single oral doses of three antidepressants: reboxetine (4 mg), a selective noradrenaline reuptake inhibitor, fluvoxamine (100 mg), a selective serotonin reuptake inhibitor, and amitriptyline (100 mg), a tricyclic antidepressant of known sedative property, upon spontaneous pupillary fluctuations in healthy male volunteers (n=16). Methods: Using… CONTINUE READING
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