Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.

@article{Chand2005ComparisonOT,
  title={Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.},
  author={Pooran Chand and Shanta Bantia and Pravin L Kotian and Yahya El-Kattan and T Lin and Yarlagadda S. Babu},
  journal={Bioorganic & medicinal chemistry},
  year={2005},
  volume={13 12},
  pages={4071-7}
}
Cyclopentane derivatives, designated as BCX-1812, BCX-1827, BCX-1898, and BCX-1923, were tested in parallel with oseltamivir carboxylate and zanamivir for the in vivo activity in mice infected with A/Turkey/Mas/76 X A/Beijing/32/92 (H6N2) influenza virus. The compounds were tested orally and intranasally at different dose levels. BCX-1812, BCX-1827, and BCX-1923 showed more than 50% protection at 1mg/kg/day dose level on oral treatment. The intranasal treatment was 100% effective even at 0.01… CONTINUE READING

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