Comparison of the antagonistic activity of tamsulosin and doxazosin at vascular α1-adrenoceptors in humans

Abstract

α1-Adrenoceptor blockers such as prazosin and doxazosin are used to treat hypertension as well as benign prostatic hyperplasia (BPH), whereas the new αl-adrenoceptor blocker tamsulosin is used only for BPH and does not reduce blood pressure at the doses used to relax prostatic smooth muscle. In contrast to prazosin, tamsulosin has a higher affinity for… (More)
DOI: 10.1007/BF00170828

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