Comparison of the actions of acebutolol, practolol and propranolol on calcium transport by heart microsomes and mitochondria.

@article{Dhalla1976ComparisonOT,
  title={Comparison of the actions of acebutolol, practolol and propranolol on calcium transport by heart microsomes and mitochondria.},
  author={Naranjan S. Dhalla and Sheu Lun Lee},
  journal={British journal of pharmacology},
  year={1976},
  volume={57 2},
  pages={215-21}
}
1 The effects of acebutolol, practolol and propranolol (0,5-3 mM) on calcium uptake, calcium binding and ATPase activities of the rabbit and rat heart microsomal and mitochondrial fractions were investigated. 2 Dose-response and time course experiments revealed that propranolol greatly inhibited microsomal and mitochondrial calcium uptake whereas both acebutolol and practolol showed slight depressant effects. 3 The ATPase activities of microsomal and mitochondrial fractions were decreased by… CONTINUE READING