Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.

@article{Jarvis2002ComparisonOT,
  title={Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.},
  author={Michael F. Jarvis and Joe P Mikusa and Katharine L. Chu and Carol T. Wismer and Prisca Honore and Elizabeth A Kowaluk and Steve P McGaraughty},
  journal={Pharmacology, biochemistry, and behavior},
  year={2002},
  volume={73 3},
  pages={573-81}
}
Inhibitors of adenosine kinase (AK) enhance extracellular concentrations of the inhibitory neuromodulator adenosine (ADO) at sites of tissue hyperexcitability and produce antinociceptive effects in animal models of pain and inflammation. The present study compared the ability of several novel and selective AK inhibitors and ADO receptor-selective agonists to attenuate carrageenan-induced thermal hyperalgesia and to impair motor performance as measured by effects on exploratory motor activity… CONTINUE READING

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