Comparison of the Treatment Guidelines for Actinic Keratosis: A Critical Appraisal and Review

@article{Fleming2017ComparisonOT,
  title={Comparison of the Treatment Guidelines for Actinic Keratosis: A Critical Appraisal and Review},
  author={Patrick J. Fleming and Stephanie Zhou and R Bobotsis and Charles W. Lynde},
  journal={Journal of Cutaneous Medicine and Surgery},
  year={2017},
  volume={21},
  pages={408 - 417}
}
There are currently several reputable guidelines on the treatment of actinic keratosis (AK) from groups in Canada, the United Kingdom, and Europe. These recommendations, based on evidence or expert consensus, offer clinicians a variety of treatment options for the different clinical presentations of AKs. Although the guidelines are similar in some regards, variations exist in treatment options, duration, and strength of recommendation. Some guidelines also lack input on specific therapies and… 
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Italian expert consensus paper on the management of patients with actinic keratoses
TLDR
Oral nicotinamide 500 mg twice daily, systemic retinoids and regular sunscreen use were demonstrated to reduce the number of new squamous cell carcinomas in patients with AKs, and Photodynamic therapy is the most studied treatment for AKs on the arms.
A Review of Existing Therapies for Actinic Keratosis: Current Status and Future Directions
TLDR
Given the aging population and therefore the increasing incidence of AK and cutaneous field carcinogenesis, further updates on the long-term efficacy of current therapies and new investigational agents are critical to guide treatment choice.
The Overall Number of Actinic Keratosis Lesions Is Not Predictable by the Number of Visible Lesions: Consequences for Field-Directed Therapies
1% Tirbanibulin Ointment for the Treatment of Actinic Keratoses
TLDR
Tirbanibulin effectively reduces AK burden and recurrence and has a favorable safety profile with mild adverse events, compared with imiquimod, 5-flourouracil, and diclofenac, which can result in necrosis, angioedema, and arthralgias.
Efficacy of topical imiquimod 3.75% in the treatment of actinic keratosis of the scalp in immunosuppressed patients: our case series
TLDR
Topical Imiquimod 3.75% represents an effective and safe treatment for multiple AK of the scalp also in immunosuppressed patients, and to the best of the knowledge, this is the first report on the use of this drug in this category of subjects.
Swiss (German) Version of the Actinic Keratosis Quality of Life questionnaire
TLDR
A Swiss (German) version of the AKQoL questionnaire applicable for the population of a university center in Switzerland is culturally adapted and validated to measure and monitor the quality of life in patients with AK.
Intensity of Local Skin Reactions During 5-Fluorouracil Treatment Related to the Number of Actinic Keratosis Lesions: A Post Hoc, Exploratory Analysis
TLDR
Local skin reactions appeared to be more severe in patients with more than 10 actinic keratosis lesions at baseline than in those with 5 to 10 lesions, and treatment with 5-fluorouracil 4% cream OD was associated with less severe local skin reactions than 5- fluorouredacil 5% BID.
Use and Cost of Actinic Keratosis Destruction in the Medicare Part B Fee-for-Service Population, 2007 to 2015
TLDR
The findings suggest that actinic keratosis imposes continuously increasing levels of treatment burden in the Medicare fee-for-service population.
Dermoscopic Monitoring for Treatment and Follow-Up of Actinic Keratosis With 5-Aminolaevulinic Acid Photodynamic Therapy
TLDR
Dermoscopy can be a useful tool for monitoring the skin lesions in patients with actinic keratosis during photodynamic therapy and follow-up, and in the dermoscopic group, 1 of 35 actinic Keratosis lesions showed recurrence of disease after 6 months of treatment.
Healthcare utilization and management of actinic keratosis in primary and secondary care: a complementary database analysis
TLDR
The high prevalence of actinic keratosis (AK) requires the optimal use of healthcare resources to improve patient care and reduce unnecessary hospital admissions.
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References

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TLDR
The Cancer Council of Australia/Australian Cancer Network guideline had the highest mean scores and was the only guideline to include a systematic review, include an evidence rating for recommendations, and report conflicts of interest and funding sources.
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TLDR
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TLDR
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TLDR
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Actinic keratosis (AK) is a frequent health condition attributable to chronic exposure to ultraviolet radiation. Several treatment options are available and evidence based guidelines are missing.
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TLDR
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TLDR
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