Comparison of the RNA polymerase I-, II- and III-dependent transcript levels between nuclear transfer and in vitro fertilized embryos at the blastocyst stage.

@article{Suzuki2007ComparisonOT,
  title={Comparison of the RNA polymerase I-, II- and III-dependent transcript levels between nuclear transfer and in vitro fertilized embryos at the blastocyst stage.},
  author={T. Suzuki and Naojiro Minami and Tomohiro Kono and Hiroshi Imai},
  journal={The Journal of reproduction and development},
  year={2007},
  volume={53 3},
  pages={663-71}
}
Cloned animals have been produced in several mammalian species so far, although success rates to term are very low. Aberrations in gene expression derived from abnormal epigenetic status have been thought to be a cause of developmental abnormalities in clones, and several abnormalities in gene expression have already been detected in cloned animals and embryos. In this study, we examined the hypothesis that the poor survival rates of nuclear transfer (NT) embryos are partly due to aberrations… CONTINUE READING
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