Comparison of the Pharmacokinetics of S-1, an Oral Anticancer Agent, in Western and Japanese Patients

Abstract

Objective: S-1 is an oral anticancer agent combining tegafur (FT), a prodrug of 5-fluorouracil (5-FU), with potassium oxonate (oteracil) and gimeracil (CDHP) respectively to mitigate gastrointestinal toxicity and increase the half-life of 5-FU. This article presents a population pharmacokinetic analysis of these four compounds in Western cancer patients… (More)
DOI: 10.1023/A:1026142601822

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Cite this paper

@article{Comets2003ComparisonOT, title={Comparison of the Pharmacokinetics of S-1, an Oral Anticancer Agent, in Western and Japanese Patients}, author={Emmanuelle Comets and Kazumasa Ikeda and Paulo Marcelo Gehm Hoff and Pierre Fumoleau and Jantien Wanders and Yusuke Tanigawara}, journal={Journal of Pharmacokinetics and Pharmacodynamics}, year={2003}, volume={30}, pages={257-283} }