Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β.

  title={Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β.},
  author={George G. J. M. Kuiper and Bo Carlsson and Kaj Grandien and Eva Enmark and Johan Ha Ggblad and Stefan Nilsson and Jan-A Ke Gustafsson},
  volume={138 3},
The rat estrogen receptor (ER) exists as two subtypes, ERa and ERb, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain. In this study we investigated the messenger RNA expression of both ER subtypes in rat tissues by RT-PCR and compared the ligand binding specificity of the ER subtypes. Saturation ligand binding analysis of in vitro synthesized human ERa and rat ERb protein revealed a single binding component for 16a-iodo-17b-estradiol with high… CONTINUE READING
Highly Influential
This paper has highly influenced 32 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 399 extracted citations


Publications referenced by this paper.
Showing 1-10 of 53 references

Mechanisms of action of steroid hormones

  • JH Clark, WT Schrader, BW O’Malley
  • Textbook of Endocrinology. WB Saunders Company…
  • 1992
Highly Influential
6 Excerpts

Estrogens. In: Munson PL (ed) Principles of Pharmacology. Basic Concepts and Clinical Applications

  • KS Korach, S Migliaccio, VL Davis
  • 1995
Highly Influential
5 Excerpts

Cloning of a novel estrogen receptor expressed in rat prostate and ovary

  • Kuiper GGJM, E Enmark, M Pelto-Huikko, S Nilsson, JÅ Gustafsson
  • Proc Natl Acad Sci USA
  • 1996

Estrogen responses in estrogen receptor-disrupted mice: an in vivo autoradiographic and in situ hybridization study

  • I Merchenthaler, PJ Shughrue, DB Lubahn, A Negro-Vilar, KS Korach
  • Program of the 10th International Congress of…
  • 1996
1 Excerpt

Physiological effects of pure antiestrogens

  • AE Wakeling
  • 1996

Physiological effects of pure antiestrogens. In: Katzenellenbogen BS, Pasqualini JR (eds) Hormone-Dependent Cancer

  • AE Wakeling
  • 1996
1 Excerpt

Similar Papers

Loading similar papers…