Comparison of the Fatal Toxicity Index of Zopiclone with Benzodiazepines

@article{Reith2003ComparisonOT,
  title={Comparison of the Fatal Toxicity Index of Zopiclone with Benzodiazepines},
  author={David M. Reith and John S. Fountain and Rebecca McDowell and Murray W Tilyard},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2003},
  volume={41},
  pages={975 - 980}
}
Abstract Background. Zopiclone is a hypnosedative structurally unrelated to the benzodiazepines but operating at the same receptor complex. Although zopiclone has been used in clinical practice for many years, relatively little is known of its relative toxicity in comparison with other hypnosedatives. Method. Deaths, where hypnosedatives were implicated, in New Zealand (NZ) in 2001 were identified from a chemical injury database. Prescription and aggregate defined daily dose (DDD) data for NZ… 
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Alprazolam was significantly more toxic than other benzodiazepines and the increased prescription of alpazolam to groups with an increased risk of deliberate self poisoning is concerning and needs review.
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