Comparison of the Extrapancreatic Action of BRX‐220 and Pioglitazone in the High‐Fat Diet‐Induced Insulin Resistance

  title={Comparison of the Extrapancreatic Action of BRX‐220 and Pioglitazone in the High‐Fat Diet‐Induced Insulin Resistance},
  author={Elena {\vS}eb{\"o}kov{\'a} and M{\'a}ria K{\"u}rthy and Tam{\'a}s Mogyor{\'o}si and K{\'a}roly Nagy and E Demc{\'a}kov{\'a} and Jozef Ukropec and Laszlo I Koranyi and Iwar Klime{\vs}},
  journal={Annals of the New York Academy of Sciences},
Abstract: A new Biorex molecule, BRX‐220, has been shown to be effective in animal models of diabetic neuro‐ and retinopathy. Recent in vitro studies showed that it might also have an insulin‐sensitizing action. Therefore, the effect of BRX‐220 on insulin sensitivity was compared with the action of pioglitazone (PGZ) in high fat (HF) diet‐induced insulin resistance (IR) of rats. Methods—Male Wistar rats were fed for 3 weeks a standard chow (PD) or the HF (70‐cal%) diet. The HF‐fed rats were… 
Protective effect of boswellic acids versus pioglitazone in a rat model of diet-induced non-alcoholic fatty liver disease: influence on insulin resistance and energy expenditure
Data from this study indicated that boswellic acids might be a promising therapy in the clinical management of NAFLD if appropriate safety and efficacy data are available.
Rebound Weight Gain Worsen the Experimental NonAlcoholic Fatty Liver Disease in Rats
Diet cycling had a negative influence on NAFLD and interfered with normal liver function and rebound weight gain suggest that rebound weight loss negatively affect the course ofNAFLD.
Ameliorative effect of Ruzu herbal bitters on high-fat diet induced non-alcoholic fatty liver disease in Wistar rats
Resumen Context : One of the world's most widespread and frequent liver diseases is the non-alcoholic fatty liver disease (NAFLD). Aims : To evaluate the preventives activities of Ruzu herbal bitters
HSP72 protects against obesity-induced insulin resistance
An essential role is identified for HSP72 in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding and protection against diet- or obesity-induced hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance.
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The effect of BRX-220 on peripheral neuropathy was examined in rats with diabetes (type 1) induced by administration of a -cell toxin, streptozotocin (STZ, 45 mg/kg iv), and nerve functions were evaluated by electrophysiological measurements of muscle motor and sensory nerve conduction velocities.


Syndromes of Insulin Resistance in the Rat: Inducement by Diet and Amelioration with Benfluorex
The hypothesis that the development of muscle insulin resistance in these models is linked to local or systemic oversupply of lipid is supported and the parallel effect of benfluorex on insulin resistance, lipids, and hypertension may prove useful in the search for the mechanisms that underlie the human disorders associated with insulin resistance.
The effect of the new oral hypoglycemic agent A-4166 on glucose turnover in the high fat diet-induced and/or in the hereditary insulin resistance of rats.
A single bolus administration of A-4166 to the control or to the insulin resistant hHTg rats, fed either the BD or HF diets, did not abolish the reduction of GIR required to maintain euglycemia during hyperinsulinemic clamps but nevertheless, A- 4166 caused a significant increase of the estimated plasma glucose disposal (Rd) and skeletal muscle glucose metabolic index (Rg') of hHTG rats fed the HF diet.
The Role of Troglitazone in Treating the Insulin Resistance Syndrome
Troglitazone, the first in a new class of drugs, directly decreases insulin resistance by improving insulin‐mediated glucose disposal and reduces plasma insulin concentrations and when combined with these agents offers additional plasma glucose reduction.
Triglycerides, fatty acids and insulin resistance--hyperinsulinemia.
  • E. Kraegen, G. Cooney, J. Ye, A. Thompson
  • Biology
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 2001
Evidence is growing that excess muscle and liver lipid accumulation causes or exacerbates insulin resistance in Syndrome X and in Type II diabetes; development of strategies to prevent this seem very worthwhile.
A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.
The results suggest that PPAR-alpha agonism has a protective effect against abnormal lipid metabolism in liver of obese rats.
Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
Mechanisms of Liver and Muscle Insulin Resistance Induced by Chronic High-Fat Feeding
In the insulin-resistant HFF rat, acute hyperinsulinemia fails to quench elevated muscle and liver lipid availability, and evidence is provided for pivotal involvement of G-6-Pase and GK in the regulation of HGP by insulin, independent of the glucose source.
Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid
It is concluded that the particular fatty acids and the lipid environment in which they are presented in high-fat diets determine insulin sensitivity in rats and impaired insulin action in skeletal muscle relates to triglyceride accumulation, suggesting intracellular glucose–fatty acid cycle involvement.
Fish oil prevents insulin resistance induced by high-fat feeding in rats.
In rats fed high-fat diets, replacement of only 6 percent of the linoleic omega-6 fatty acids from safflower oil with long-chain polyunsaturated omega-3 fatty acids with fish oil prevented the development of insulin resistance.