Comparison of the E3 and L3 regions for arming oncolytic adenoviruses to achieve a high level of tumor-specific transgene expression

@article{Robinson2008ComparisonOT,
  title={Comparison of the E3 and L3 regions for arming oncolytic adenoviruses to achieve a high level of tumor-specific transgene expression},
  author={Mark Robinson and Y Ge and Derek Ko and Satya Yendluri and Guillaume Laflamme and L Hawkins and Karin Jooss},
  journal={Cancer Gene Therapy},
  year={2008},
  volume={15},
  pages={9-17}
}
Arming oncolytic adenoviral vectors with anticancer transgenes that can be expressed in a tumor-selective manner may enable the engineering of vectors with increased potency, while retaining their safety profile. Armed oncolytic adenoviral vectors were constructed in which transgene expression has been linked via modified splice acceptor sequences that did not necessitate the deletion of any part of the adenoviral genome. Several oncolytic adenoviral vectors were compared in which the transgene… CONTINUE READING