Comparison of the Analgesic Dose‐Effect Relationships of Nefopam and Oxycodone in Postoperative Pain

  title={Comparison of the Analgesic Dose‐Effect Relationships of Nefopam and Oxycodone in Postoperative Pain},
  author={Irma Tigerstedt and Tapani Tammisto and Per Leander},
  journal={Acta Anaesthesiologica Scandinavica},
The analgesic dose‐effect relationship of nefopam was compared in a double‐blind randomised trial with that of oxycodone in immediate postoperative pain. Nefopam 15 mg or oxycodone 4 mg was given every 10 min i.v. (maximum six times) to patients in pain after upper abdominal surgery until their wound pain (scored 0–3) disappeared. The mean pain intensity (PI), initially 2.2 in both groups, decreased by approximately the same extent for up to two doses in both groups (to 1.5 after nefopam 30 mg… 

Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection*

Postoperative intravenous patient‐controlled analgesia with morphine alone, or in combination with nefopam or propacetamol, given at their highest recommended doses resulted in a halved cumulative morphine consumption and overall patient satisfaction was better than in the control group.

The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study

The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.

Opioid sparing effect and safety of nefopam in patient controlled analgesia after laparotomy: A randomized, double blind study

Intravenous PCA using nefopam + fentanyl following laparotomy has an opioid sparing effect and is associated with a low incidence of some of the typical opioid related adverse events.

The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study

PCA with nefopam alone provides suitable postoperative analgesia after cardiac surgery and there were no significant between-group differences in VAS score, total PCA infusion volume or number of rescue injections.

Single dose oral nefopam for acute postoperative pain in adults.

In the absence of evidence of efficacy for oral nefopam in acute postoperative pain, its use in this indication is not justified and use in other indications should be evaluated carefully.

Single dose oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain.

Single-dose oral oxycodone, with or without paracetamol, appears to be of comparable efficacy to intramuscular morphine and non-steroidal anti-inflammatory drugs.

Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients.

A single slow infusion of nefopam is effective in critically ill patients who have moderate pain and the risk of tachycardia and increased cardiac output and also hypotension and decreased systemic vascular resistance should be known to evaluate the benefit/risk ratio of its prescription.

Rediscovery of Nefopam for the Treatment of Neuropathic Pain

The recently discovered dual analgesic mechanisms of action, namely, descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain.

Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults.

Single dose oxycodone is an effective analgesic in acute postoperative pain at doses over 5 mg; oxy codone is two to three times stronger than codeine; Efficacy increases when combined with paracetamol.

Nefopam: A Review of its Pharmacological Properties and Therapeutic Efficacy

Nefopam is a non-narcotic analgesic not structurally related to other analgesic drugs, and when appropriate dose ratios were compared in short term studies it was shown to produce analgesia comparable to that with the oral analgesics aspirin, dextropropoxyphene and pentazocine, as well as that with ‘moderate’ doses of parenteral morphine, pethidine and pentacine.



Comparison of nefopam and pethidine in postoperative pain.

A double-blind, between-patient, two-dose comparison was performed with pethidine and nefopam in 100 subjects, the majority of whom were recovering from upper abdominal surgery, finding the former being not more effective than neFopam 15 mg apart from the duration of analgesia which was longer.

Controlled Clinical Trial of Oral and Parenteral Nefopam Hydrochloride. A Novel and Potent Analgesic Drug

Nefopam is a potent analgesic of novel structure and unique physiologic properties that is distinctly superior to placebo in analgesic effectiveness, both in the initial single dose and in maintaining therapeutic benefit for the duration of the three-day trial.

Nefopam and morphine in man

A comparison was made of morphine and nefopam in 74 patients who required parenteral analgesia for moderate to severe postoperative and somatic pain, using a single administration, 2‐dose level, double‐blind design.

Respiratory effects of nefopam

Arespiratory study has been done to compare the respiratory effects of a potent new analgesic, nefopam, to morphine. Morphine was a potent respiratory depressant at therapeutic dosage while nefopam

of clinical

  • Education
of the possible factors affecting the educational attendance of faculty members were extracted. This list of factors was completed by the ideas generated in brainstorming sessions. Viewpoints of the

A clinical evaluation of nefopam hydrochloride (Acupan): a new analgesic.

Nefopam hydrochloride for pain relief.

  • A. Cohen
  • Medicine
    Current therapeutic research, clinical and experimental
  • 1974

Krcislauf und Coronardurcliblutung unter Nefopam

  • Nefopam Workshop, Bad Nauheim,
  • 1978