Comparison of the Analgesic Dose‐Effect Relationships of Nefopam and Oxycodone in Postoperative Pain

@article{Tigerstedt1979ComparisonOT,
  title={Comparison of the Analgesic Dose‐Effect Relationships of Nefopam and Oxycodone in Postoperative Pain},
  author={Irma Tigerstedt and Tapani Tammisto and Per Leander},
  journal={Acta Anaesthesiologica Scandinavica},
  year={1979},
  volume={23}
}
The analgesic dose‐effect relationship of nefopam was compared in a double‐blind randomised trial with that of oxycodone in immediate postoperative pain. Nefopam 15 mg or oxycodone 4 mg was given every 10 min i.v. (maximum six times) to patients in pain after upper abdominal surgery until their wound pain (scored 0–3) disappeared. The mean pain intensity (PI), initially 2.2 in both groups, decreased by approximately the same extent for up to two doses in both groups (to 1.5 after nefopam 30 mg… 

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Single dose oral nefopam for acute postoperative pain in adults.

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Single dose oxycodone and oxycodone plus paracetamol (acetominophen) for acute postoperative pain.

Single-dose oral oxycodone, with or without paracetamol, appears to be of comparable efficacy to intramuscular morphine and non-steroidal anti-inflammatory drugs.

Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients.

A single slow infusion of nefopam is effective in critically ill patients who have moderate pain and the risk of tachycardia and increased cardiac output and also hypotension and decreased systemic vascular resistance should be known to evaluate the benefit/risk ratio of its prescription.

Rediscovery of Nefopam for the Treatment of Neuropathic Pain

The recently discovered dual analgesic mechanisms of action, namely, descending pain modulation by triple neurotransmitter reuptake inhibition similar to antidepressants, and inhibition of long-term potentiation mediated by NMDA from the inhibition of calcium influx like gabapentinoid anticonvulsants or blockade of voltage-sensitive sodium channels like carbamazepine, enable NFP to be used as a therapeutic agent to treat neuropathic pain.

Single dose oral oxycodone and oxycodone plus paracetamol (acetaminophen) for acute postoperative pain in adults.

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