Comparison of tests for association and linkage in incomplete families.

@article{Cervino2000ComparisonOT,
  title={Comparison of tests for association and linkage in incomplete families.},
  author={Alessandra C.L. Cervino and Adrian V S Hill},
  journal={American journal of human genetics},
  year={2000},
  volume={67 1},
  pages={120-32}
}
To analyze incomplete families, the following statistical tests can be used: LRAT-a simple likelihood-based association test, TRANSMIT, SIBASSOC/STDT, and RCTDT. We compared these four tests, for the diallelic case, on simulated data sets. The comparisons focused on the power to detect linkage and association when different familial structures, resistance to population stratification, resistance to misclassification of the disease status of the healthy sib, and the effect of nonpaternity were… CONTINUE READING

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