Comparison of tebufelone distribution in rat blood plasma and inflamed and noninflamed tissues following peroral and intravenous administration.

@article{Doyle1993ComparisonOT,
  title={Comparison of tebufelone distribution in rat blood plasma and inflamed and noninflamed tissues following peroral and intravenous administration.},
  author={Matthew J. Doyle and Thomas H. Eichhold and M. E. Loomans and Robert W. Farmer and Gary R. Kelm},
  journal={Journal of pharmaceutical sciences},
  year={1993},
  volume={82 8},
  pages={847-50}
}
It is recognized that some acidic nonsteroidal antiinflammatory drugs (NSAIDs) accumulate in the synovial fluids of inflamed joints. The distribution of tebufelone, a member of the di-tert-butylphenol class of NSAIDs, between rat plasma and paw tissues (inflamed and noninflamed) was determined. Tebufelone was administered (doses providing 80% maximal… CONTINUE READING