Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients

@article{Lauretti2003ComparisonOS,
  title={Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients},
  author={Gabriela Rocha Lauretti and Gl{\'a}ucia Maria Cavasin Oliveira and Newton L Pereira},
  journal={British Journal of Cancer},
  year={2003},
  volume={89},
  pages={2027 - 2030}
}
The antinociceptive effect of morphine and oxycodone is mediated preferentially at μ and κ receptors, respectively. The aim of this study was to evaluate the analgesic profile of the combination of morphine and oxycodone in cancer pain, compared to the standard administration of morphine alone. Controlled-release formulations of oxycodone (CRO) and morphine (CRM) were compared in 26 patients. The study started with an open-label, randomised titration phase to achieve stable pain control for 7… CONTINUE READING
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