Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases.

Abstract

Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly expressed in the human liver, where carboxylesterase (CES) enzymes, namely, CES1 and CES2, are also expressed. It is generally recognized that CES1 prefers compounds with a large acyl… (More)
DOI: 10.1016/j.ejps.2015.07.006

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