Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits

  title={Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits},
  author={N. Franceschini and M. Wojczynski and H. G{\"o}ring and J. Peralta and T. Dyer and Xia Li and H. Li and K. North},
  journal={BMC Proceedings},
  pages={S85 - S85}
  • N. Franceschini, M. Wojczynski, +5 authors K. North
  • Published 2007
  • Medicine
  • BMC Proceedings
  • In order to identify regulatory genes, we determined the heritability of gene transcripts, performed linkage analysis to identify quantitative trait loci (QTLs), and evaluated the evidence for shared genetic effects among transcripts with co-localized QTLs in non-diseased participants from 14 CEPH (Centre d'Etude du Polymorphisme Humain) Utah families. Seventy-six percent of transcripts had a significant heritability and 54% of them had LOD score ≥ 1.8. Bivariate genetic analysis of 15… CONTINUE READING
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