Comparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125.

@article{Kassis1999ComparisonOS,
  title={Comparison of strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125.},
  author={Amin I. Kassis and Ravi S. Harapanhalli and S. James Adelstein},
  journal={Radiation research},
  year={1999},
  volume={151 2},
  pages={
          167-76
        }
}
To elucidate the kinetics of the induction of DNA strand breaks by low-energy Auger electron emitters, we compared the yields of DNA breaks in supercoiled pUC19 DNA after the decay of 125I (1) in proximity to DNA after minor-groove binding (125I-iodoHoechst 33342, 125IH) and (2) at a distance from DNA (125I-iodoantipyrine, 125IAP). Iodine-125 bound to the minor groove in DNA or free in solution is equally effective per decay in producing single-strand breaks (SSBs), while 125I bound to the… CONTINUE READING
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