Comparison of stepwise addition of prandial insulin to a basal-bolus regimen when basal insulin is insufficient for glycaemic control in type 2 diabetes: results of the OSIRIS study.

@article{Raccah2012ComparisonOS,
  title={Comparison of stepwise addition of prandial insulin to a basal-bolus regimen when basal insulin is insufficient for glycaemic control in type 2 diabetes: results of the OSIRIS study.},
  author={D Raccah and Thomas Haak and Dominique Huet and Louis Monnier and David P. Robertson and P Labard and Josep J. Masdemont Soler and Alfred Penfornis},
  journal={Diabetes & metabolism},
  year={2012},
  volume={38 6},
  pages={
          507-14
        }
}
AIM The metabolic efficacy of adding prandial insulin in a stepwise manner to a straightforward basal-bolus regimen was compared in patients with type 2 diabetes mellitus (T2DM), suboptimally controlled by oral antidiabetic drugs (OADs) and once-daily basal insulin. METHODS In this international randomized, parallel-group, non-inferiority study, 811 patients with poorly controlled type 2 diabetes using basal insulin were switched to insulin glargine (GLAR) for 6 months while continuing OADs… CONTINUE READING

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Stepwise addition of prandial insulin.

The lancet. Diabetes & endocrinology • 2014

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