Comparison of statistical power between 2 * 2 allele frequency and allele positivity tables in case-control studies of complex disease genes.

@article{Ohashi2001ComparisonOS,
  title={Comparison of statistical power between 2 * 2 allele frequency and allele positivity tables in case-control studies of complex disease genes.},
  author={Jun Ohashi and Shuji Yamamoto and Naoyuki Tsuchiya and Yoshihiro Hatta and Takafumi Komata and Masakazu Matsushita and Katsushi Tokunaga},
  journal={Annals of human genetics},
  year={2001},
  volume={65 Pt 2},
  pages={197-206}
}
In case-control studies of complex disease genes, allele frequencies or allele positivities at candidate loci or markers are compared between cases and controls. Although 2 x 2 contingency tables based on allele frequency and allele positivity are generally used to perform simple statistical tests (e.g. a comparison of two proportions and a chi2 test), little is known about the difference in power between the two tables. In this study, we investigated the number of subjects required to obtain a… CONTINUE READING