Comparison of standard and low serum levels of lithium for maintenance treatment of bipolar disorder.

@article{Gelenberg1989ComparisonOS,
  title={Comparison of standard and low serum levels of lithium for maintenance treatment of bipolar disorder.},
  author={Alan J. Gelenberg and John M. Kane and M. Bernhard Keller and Philip W. Lavori and Jerrold F. Rosenbaum and Kristen M. Cole and James P. Lavelle},
  journal={The New England journal of medicine},
  year={1989},
  volume={321 22},
  pages={
          1489-93
        }
}
In recent years, lower serum levels have been recommended for maintenance therapy with lithium. We studied 94 patients with bipolar disorder in a randomized, double-blind, prospective trial of two different doses of lithium for maintenance therapy: the "standard" dose, adjusted to achieve a serum lithium concentration of 0.8 to 1.0 mmol per liter, and a "low" dose, resulting in a serum concentration of 0.4 to 0.6 mmol per liter. The group medians of the patients' average serum lithium levels… CONTINUE READING
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