Comparison of solution-based exome capture methods for next generation sequencing

  title={Comparison of solution-based exome capture methods for next generation sequencing},
  author={Anna-Maija Sulonen and Pekka Ellonen and Henrikki Almusa and Maija Lepist{\"o} and Samuli Eldfors and Sari Hannula and Timo A. Miettinen and Henna Tyynismaa and Perttu P. Salo and Caroline A Heckman and Heikki Joensuu and Taneli Raivio and Anu Suomalainen and Janna Saarela},
  booktitle={Genome Biology},
Techniques enabling targeted re-sequencing of the protein coding sequences of the human genome on next generation sequencing instruments are of great interest. We conducted a systematic comparison of the solution-based exome capture kits provided by Agilent and Roche NimbleGen. A control DNA sample was captured with all four capture methods and prepared for Illumina GAII sequencing. Sequence data from additional samples prepared with the same protocols were also used in the comparison. We… CONTINUE READING
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