Comparison of soluble dopamine D2-receptors from three species.

  title={Comparison of soluble dopamine D2-receptors from three species.},
  author={Bertha K. Madras and Alistair Davis and Philip Seeman},
  journal={European journal of pharmacology},
  volume={78 4},
In order to determine the species which would provide the highest yield of soluble and specific D2-type dopamine receptors, the striata from human, calf and canine brains were solubilized by 1% digitonin. The receptors were detected with [3H]spiperone, using Sephadex G-50 columns or polyethylene glycol precipitation. The soluble D2-sites from the human and… CONTINUE READING