Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE‐high extrinsic and IgE‐normal intrinsic types of atopic dermatitis

@article{Mori2010ComparisonOS,
  title={Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE‐high extrinsic and IgE‐normal intrinsic types of atopic dermatitis},
  author={T. Mori and K. Ishida and S. Mukumoto and Y. Yamada and G. Imokawa and K. Kabashima and M. Kobayashi and T. Bito and M. Nakamura and K. Ogasawara and Y. Tokura},
  journal={British Journal of Dermatology},
  year={2010},
  volume={162}
}
Background  Two types of atopic dermatitis (AD) have been proposed, with different pathophysiological mechanisms underlying this seemingly heterogeneous disorder. The extrinsic type shows high IgE levels presumably as a consequence of skin barrier damage and feasible allergen permeation, whereas the intrinsic type exhibits normal IgE levels and is not mediated by allergen‐specific IgE. 
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