Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome.

@article{ElkindHirsch2008ComparisonOS,
  title={Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome.},
  author={Karen Elkind-Hirsch and Ory Marrioneaux and Madhu Bhushan and Denise Vernor and Rajat Bhushan},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 7},
  pages={2670-8}
}
CONTEXT Insulin resistance and obesity are common features of the polycystic ovary syndrome (PCOS). Weight loss and use of insulin-lowering drugs have been shown to improve both reproductive and metabolic aspects of PCOS. OBJECTIVE We evaluated exenatide (EX) and metformin (MET), alone and in combination (COM), on menstrual cyclicity, hormonal parameters, metabolic profiles, and inflammatory markers in overweight, insulin-resistant women with PCOS. DESIGN, SETTING, AND PARTICIPANTS Sixty… CONTINUE READING