Comparison of single, fractionated and hyperfractionated irradiation on the development of normal tissue damage in rat lung.

@article{Giri1985ComparisonOS,
  title={Comparison of single, fractionated and hyperfractionated irradiation on the development of normal tissue damage in rat lung.},
  author={Prachi Suresh Giri and Bruce F Kimler and U. P. Giri and Gail G. Cox and E. Rama Krishna Reddy},
  journal={International journal of radiation oncology, biology, physics},
  year={1985},
  volume={11 3},
  pages={
          527-34
        }
}
The effect of fractionated thoracic irradiation on the development of normal tissue damage in rats was compared to that produced by single doses. Animals received a single dose of 15 Gy, 30 Gy in 10 daily fractions of 3 Gy each (fractionation), or 30 Gy in 30 fractions of 1 Gy each 3 times a day (hyperfractionation). The treatments produced minimal lethality since a total of only 6 animals died between days 273 and 475 after the initiation of treatment, with no difference in survival observed… CONTINUE READING
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