Comparison of short and long half‐life benzodiazepine hypnotics: Triazolam and quazepam

@article{Kales1986ComparisonOS,
  title={Comparison of short and long half‐life benzodiazepine hypnotics: Triazolam and quazepam},
  author={Anthony Kales and Edward O. Bixler and Antonio Vela‐bueno and Constantin R. Soldatos and Douglas E Nikiaus and Rocco L. Manfredi},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1986},
  volume={40}
}
Two benzodiazepine hypnotics, triazolam, 0.25 mg, with a short elimination t1/2, and quazepam, 15 mg, with a long t1/2, were evaluated in 22‐night sleep laboratory studies. Quazepam improved sleep significantly during both short‐ and intermediate‐term use. Daytime sleepiness, which decreased with continued use, was the side effect most often associated with quazepam dosing. In contrast, triazolam dosing did not significantly improve any of the major sleep efficiency parameters, and there was a… 
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