Comparison of serum iron, total iron binding capacity, ferritin, and percent transferrin saturation in nine species of apparently healthy captive lemurs

@article{Williams2006ComparisonOS,
  title={Comparison of serum iron, total iron binding capacity, ferritin, and percent transferrin saturation in nine species of apparently healthy captive lemurs},
  author={Cathy V. Williams and Jennifer Campbell and Kelly M. Glenn},
  journal={American Journal of Primatology},
  year={2006},
  volume={68}
}
Lemurs kept in captivity have been reported to be highly prone to accumulate excessive amounts of iron in tissues (hemosiderosis). Diagnosis of the condition is most commonly made during a postmortem examination because an antemortem diagnosis requires a liver biopsy, a procedure that may not be well tolerated by all animals. The lack of a noninvasive method to evaluate iron status in captive lemurs limits investigators' ability to effectively screen animals for the presence of hemosiderosis… 
Evaluation of iron status in lemurs by analysis of serum iron and ferritin concentrations, total iron-binding capacity, and transferrin saturation.
OBJECTIVE To assess serum iron and ferritin concentrations, total iron-binding capacity, and transferrin saturation as indicators of iron metabolic status in 3 genera of lemurs and determine whether
DOSE TITRATION OF DEFERASIROX IRON CHELATION THERAPY BY MAGNETIC RESONANCE IMAGING FOR CHRONIC IRON STORAGE DISEASE IN THREE ADULT RED BALD-HEADED UAKARI (CACAJAO CALVUS RUBICUNDUS)
TLDR
Postmortem documentation of severe iron storage disease in one red bald-headed uakari and the use of iron chelation with oral deferasirox in the three surviving members of the colony are described.
Serum iron metabolites in an opportunistic sample of different captive primate species
TLDR
The findings corroborate patterns previously described in individual studies, and underline that further efforts should be made to understand the reasons and consequences of these differences in iron metabolism.
Iron storage disorders in captive wild mammals: the comparative evidence.
  • M. Clauss, D. Paglia
  • Environmental Science
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • 2012
TLDR
This report collates the comparative evidence for species' susceptibility to excessive burden of iron in captive mammal species, recognizing that the data for mammal species are limited.
Comparison of Biomedical Evaluation for White-Fronted Brown Lemurs (Eulemur fulvus albifrons) from Four Sites in Madagascar
TLDR
Comparison of health parameters between sites revealed statistically significant differences in body weight, body temperature, respiratory rate, hematology parameters, and nutrition parameters, which are likely related to season, soil, and forage availability.
The Role of Hepcidin in Regulation of Iron Balance in Bats
TLDR
While the Egyptian fruit bat exhibited significant hepcidin response to iron challenge, the magnitude of response was lower than that in the common vampire bat and lower than expected based on findings in healthy humans.
BIOMEDICAL EVALUATION OF BLACK LEMURS (EULEMUR MACACO MACACO) IN LOKOBE RESERVE, MADAGASCAR
  • R. Junge, E. Louis
  • Biology
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • 2007
TLDR
Complete medical evaluations were performed on 25 wild black lemurs (Eulemur macaco macaco) in Lokobe Reserve, northwestern Madagascar, and significant differences exist between captive and wild animals for total white blood cell count, segmented neutrophil count, band neutrophils count, eosinophil number, monocyte count, and basophil count.
The pathology of comparative animal models of human haemochromatosis.
Iron deficiency anemia in a ring-tailed lemur (Lemur catta) with concurrent chronic renal failure.
TLDR
Findings for this lemur support the use of species-specific total iron binding capacity and total serum iron and ferritin concentrations in evaluation of an animal with suspected iron deficiency.
Variation in physiological health of diademed sifakas across intact and fragmented forest at Tsinjoarivo, eastern Madagascar
TLDR
Clinical laboratory data on hematology, serum biochemistry, fat‐soluble vitamins, minerals, iron analytes, viral serology, and parasitology of diademed sifaka derived from the capture of 26 individuals spanning eight groups and two habitats at Tsinjoarivo, Madagascar suggest that fragment sifakas may be less healthy than continuous forest groups.
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