Comparison of sensitization to ambulation-increasing effects of cocaine and methamphetamine after repeated administration in mice.

@article{Hirabayashi1991ComparisonOS,
  title={Comparison of sensitization to ambulation-increasing effects of cocaine and methamphetamine after repeated administration in mice.},
  author={Masahiko Hirabayashi and Setsuro Okada and Sakutaro Tadokoro},
  journal={The Journal of pharmacy and pharmacology},
  year={1991},
  volume={43 12},
  pages={827-30}
}
The effects of repeated (5 times) subcutaneous administration of cocaine (10, 20 or 40 mg kg-1) and methamphetamine (1, 2 or 4 mg kg-1) at 3-4 day intervals have been compared in mice placed individually into tilting activity cages. A progressive enhancement of the ambulation-increasing effect was noted for 3-4 h after each administration, indicating that sensitization occurred. This occurrence and the existence of an optimal dose producing sensitization were similar for both drugs. However… CONTINUE READING