Comparison of sea anemone and scorpion toxins binding to Kv1 channels: an example of convergent evolution.

@article{Gasparini2004ComparisonOS,
  title={Comparison of sea anemone and scorpion toxins binding to Kv1 channels: an example of convergent evolution.},
  author={Sylvaine Gasparini and Bernard Gilquin and Andr{\'e} M{\'e}nez},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2004},
  volume={43 8},
  pages={901-8}
}
Comparison of data from functional mapping carried out on scorpion and sea anemones toxins blocking currents through voltage-gated potassium channels revealed that, despite their different 3D structures, the binding cores of these toxins displayed some similarities. Further molecular modeling studies suggested that these similarities reflect the use by these toxins of a common binding mode to exert their blocking function. Therefore, scorpion and sea anemone toxins offer an example of… CONTINUE READING

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