Comparison of salivary antimicrobial peptides and upper respiratory tract infections in elite marathon runners and sedentary subjects

@article{Usui2012ComparisonOS,
  title={Comparison of salivary antimicrobial peptides and upper respiratory tract infections in elite marathon runners and sedentary subjects},
  author={Tatsuya Usui and Takahiro Yoshikawa and Keisuke Orita and Shin-ya Ueda and Yoshihiro Katsura and Shigeo Fujimoto},
  journal={The Journal of Physical Fitness and Sports Medicine},
  year={2012},
  volume={1},
  pages={175-181}
}
The aim of the present study was to examine the relationship between human β-defensin-2 (HBD-2), cathelicidin (LL-37) and upper respiratory tract infections (URTI). In addition, the possible association between salivary cortisol and the salivary antimicrobial peptides was also examined. We hypothesized that the saliva levels of HBD-2 and LL-37 are lower in elite marathon runners; and that saliva cortisol levels might have a negative association with saliva HBD-2 and LL-37. Twenty elite male… 

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    International journal of sports medicine
  • 2000
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