Comparison of repeated-dose pharmacokinetics of prolonged-release and immediate-release torasemide formulations in healthy young volunteers.

@article{Barbanoj2009ComparisonOR,
  title={Comparison of repeated-dose pharmacokinetics of prolonged-release and immediate-release torasemide formulations in healthy young volunteers.},
  author={M J Barbanoj and Mar{\'i}a Rosa Ballester and Rosa M. Antonijoan and Ignasi J. Gich and Pilar Pelagio and Savion Gropper and Benjam{\'i}n Santos and Antonio Guglietta},
  journal={Fundamental & clinical pharmacology},
  year={2009},
  volume={23 1},
  pages={115-25}
}
The major aim of the study was to compare the pharmacokinetic profile of repeated-dose administration of a prolonged-release (PR) formulation of torasemide with that of an immediate-release (IR) dosage. Sixteen volunteers received one daily dose, on four consecutive days, of 10 mg of torasemide-PR or torasemide-IR in a single-blind, two-treatment, two-period, repeated-dose, cross-over, sequence-randomized clinical trial. Blood samples were collected at various time points on day 1 (single-dose… CONTINUE READING

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