Comparison of red cell creatine level and reticulocyte count in appraising the severity of hemolytic processes.

@article{Fehr1979ComparisonOR,
  title={Comparison of red cell creatine level and reticulocyte count in appraising the severity of hemolytic processes.},
  author={Jorg Fehr and M Knob},
  journal={Blood},
  year={1979},
  volume={53 5},
  pages={966-76}
}
In seeking a sensitive indicator for quantitative assessment of hemolytic disease, we found a close dependence of red cell creatine level on cell age. Studies in 21 patients with steady-state hemolysis showed high correlation (r=0.89, p less than 0.001) between reticulocyte counts and red cell creatine levels. Excluding elevation of the creatine level as a variable epiphenomenon of increased erythropoietic activity, density separation of normal red cells revealed distinctly higher creatine… CONTINUE READING
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