Comparison of rat and human responses to toll-like receptor 7 activation.

@article{Clarke2009ComparisonOR,
  title={Comparison of rat and human responses to toll-like receptor 7 activation.},
  author={S. Clarke and C. Laxton and N. Horscroft and Virgile Richard and A. Thomas and T. Parkinson},
  journal={Journal of interferon \& cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2009},
  volume={29 2},
  pages={
          113-26
        }
}
  • S. Clarke, C. Laxton, +3 authors T. Parkinson
  • Published 2009
  • Medicine, Biology
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Toll-like receptors recognize invading microorganisms and activate innate immune responses. Their discovery has opened up a range of therapeutic possibilities, in particular for infectious diseases. Responses to TLR agonists have been largely studied in mice and little information exists in other species. Given that rats are commonly used for pharmacokinetic and toxicology studies in drug development, we compared TLR7 responses in rat and human. Stimulation of rat and human peripheral blood… Expand

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