Comparison of quince with vitamin B6 for treatment of nausea and vomiting in pregnancy: a randomised clinical trial

  title={Comparison of quince with vitamin B6 for treatment of nausea and vomiting in pregnancy: a randomised clinical trial},
  author={Effat Jafari-Dehkordi and Fataneh Hashem-Dabaghian and Fatemeh Aliasl and Jale Aliasl and Maryam Taghavi-Shirazi and Omid Sadeghpour and Farnaz Sohrabvand and Bagher Minaei and Roshanak Ghods},
  journal={Journal of Obstetrics and Gynaecology},
  pages={1048 - 1052}
Abstract This trial was performed to compare quince (Cydonia oblonga) fruit with vitamin B6 on 76 pregnant women with a gestational age of 6–14 weeks and mild-to-moderate nausea and vomiting (NVP) (40 in the quince and 36 in the B6 group). The ‘Pregnancy-Unique Quantification of Emesis’ (PUQE-24) scale was used to examine the severity of NVP. The quince syrup (1 tablespoon/TDS) or vitamin B6 tablets (20 mg/TDS) were used as intervention for 1 week. The mean (±SD) age was 27.5 (±5.2) years. The… 
A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy
This systematic review confirmed the results of previous systematic reviews in a larger sample size and suggested that ginger were more effective than vitamin B, but at the dose of 35–500 mg ginger, vitamin B6 and ginger had identical effect.
Interventions for treating nausea and vomiting in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials
Ginger and vitamin B6 were associated with reduced nausea scores compared to placebo and were also associated with better vomiting control and less incidence of adverse events.
Measuring the severity of nausea and vomiting of pregnancy; a 20-year perspective on the use of the pregnancy-unique quantification of emesis (PUQE)
  • G. KorenRana Cohen
  • Psychology, Medicine
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • 2020
Twenty years ago the Pregnancy Unique Quantification of Emesis scale (PUQE) was described and validated, as a clinical and research tool and has become widely used for both ends, and has been incorporated in numerous practice guidelines worldwide.
The relationship between birth fear and psychosocial health level of nausea-vomiting severity in pregnancy: An example from Turkey
It was determined that pregnant women with severe nausea and vomiting severity had more fear of child birth than those with mild and moderate nausea and vomit severity and the increase in anxiety and stress levels and the perception of insufficient psychosocial support are important variables that increase the severity of nausea and nausea in pregnancy.
Safety classification of herbal medicines used among pregnant women in Asian countries: a systematic review
Several herbal medicines identified in this review were classified to be potentially harmful or the information regarding safety in pregnancy was missing, it is recommended that contraindicated herbal medicines should be avoided and other herbals should be taken under supervision of a qualified health care practitioner.
Herbal Medicinal Product Use During Pregnancy and the Postnatal Period
Synthesis of pooled data on herbal medicinal products used during and after pregnancy highlights the need for robust safety studies.
Nausea and vomiting of pregnancy


Comparing the Effectiveness of Vitamin B6 and Ginger in Treatment of Pregnancy-Induced Nausea and Vomiting
Vomiting was more reduced in vitamin B6 group; however, this reduction was not statistically significant, and there was no significant difference between the two groups in nausea occurrences and their duration.
Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial.
Ginger was more effective than vitamin B6 for treatment of nausea and vomiting in pregnancy and side effects from ginger were reported to be minor and did not need any treatment.
A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy.
The nausea score and the number of vomiting episodes were significantly reduced following ginger and vitamin B6 therapy, and there was no significant difference between ginger and Vitamin B6 for the treatment of nausea and vomiting during pregnancy.
Nausea and vomiting of pregnancy: using the 24-hour Pregnancy-Unique Quantification of Emesis (PUQE-24) scale.
Ondansetron Compared With Doxylamine and Pyridoxine for Treatment of Nausea in Pregnancy: A Randomized Controlled Trial
Ondansetron was found to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy and was more likely to have an improvement in their baseline nausea.
A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting
Based on evidence from this SR, ginger could be considered a harmless and possibly effective alternative option for women suffering from NVP and pose a risk for side-effects or adverse events during pregnancy.
Effects of ginger capsules on pregnancy, nausea, and vomiting.
Ginger is an effective herbal remedy for decreasing nausea and vomiting during pregnancy and can be suggested by care providers as a means of decreasing pregnancy nausea and vomit in women who tend to herbal medicines.
Prevalence of nausea and vomiting of pregnancy in the USA: a meta analysis.
  • T. EinarsonC. PiwkoG. Koren
  • Medicine
    Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique
  • 2013
Rates of NVP and HG in the USA are similar to those found in other parts of the world, which should address issues of cost and resource utilization.