Comparison of pyrolysis mass spectrometry with high performance liquid chromatography for the analysis of Cremophor EL in drugs and serum.

@article{Ghassempour2003ComparisonOP,
  title={Comparison of pyrolysis mass spectrometry with high performance liquid chromatography for the analysis of Cremophor EL in drugs and serum.},
  author={Alireza Ghassempour and Mohammad Reza Nabid and Mohammad Talebi and Ali Akbar Entezami},
  journal={Talanta},
  year={2003},
  volume={59 3},
  pages={435-41}
}
Polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL: CrEL) is a solubilization agent for hydrophobic drugs. Recently, CrEL has shown some side effects in patients. In the present work, we introduce pyrolysis-mass spectrometry (Py-MS) for the determination of CrEL in drugs and blood samples. Mass to charge (m/z) values of 89 and 138 of CrEL and 3-nitroaniline (as internal standard), respectively, were used for quantitative measurements by selected ion monitoring (SIM) method. At a probe… CONTINUE READING