Comparison of protein surfaces using a genetic algorithm

  title={Comparison of protein surfaces using a genetic algorithm},
  author={Andrew R. Poirrette and Peter J. Artymiuk and David W. Rice and Peter Willett},
  journal={Journal of computer-aided molecular design},
  volume={11 6},
A genetic algorithm (GA) is described which is used to compare the solvent-accessible surfaces of two proteins or fragments of proteins, represented by a dot surface calculated using the Connolly algorithm. The GA is used to move one surface relative to the other to locate the most similar surface region between the two. The matching process is enhanced by… CONTINUE READING