Comparison of protein active site structures for functional annotation of proteins and drug design

@article{Powers2006ComparisonOP,
  title={Comparison of protein active site structures for functional annotation of proteins and drug design},
  author={Robert Powers and Jennifer C Copeland and Katherine Germer and Kelly Mercier and Viswanathan Ramanathan and Peter Z. Revesz},
  journal={Proteins: Structure},
  year={2006},
  volume={65}
}
Rapid and accurate functional assignment of novel proteins is increasing in importance, given the completion of numerous genome sequencing projects and the vastly expanding list of unannotated proteins. Traditionally, global primary‐sequence and structure comparisons have been used to determine putative function. These approaches, however, do not emphasize similarities in active site configurations that are fundamental to a protein's activity and highly conserved relative to the global and more… Expand
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